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Blog of Weight Loss, Dieting & Obesity Research - Archive #0118.



Molecular partnership controls daily rhythms, body metabolism

November 26, 2008 - University of Pennsylvania School of Medicine / Nature

A research team has discovered a key molecular partnership that coordinates body rhythms and metabolism. Their findings suggest that HDAC via NCoR controls the body's internal clock, and therefore metabolism, through an epigenetic change


Route to obesity passes through tongue

November 26, 2008 - EurekAlert / Journal of Neurophysiology

Obesity gradually numbs the taste sensation of rats to sweet foods and drives them to consume larger and ever-sweeter meals, according to neuroscientists. Findings from the Penn State study could uncover a critical link between taste and body weight, and reveal how flab hooks the brain on sugary food


Yale researchers enlist a new recruit in battle of the bulge

November 26, 2008 - EurekAlert / Cell (also here and here)

In the battle against obesity, Yale University researchers may have discovered a new weapon -- a naturally occurring molecule called NAPE secreted by the gut that makes rats and mice less hungry after fatty meals


Research reveals mechanism linking serotonin with regulation of food intake

November 26, 2008 - EurekAlert / Neuron

Genetic mouse models have provided surprising insight into mechanisms linking serotoninergic compounds with the regulation of feeding behavior and body weight. The research pinpoints a specific group of brain cells that mediate energy balance and may lead to the development of antiobesity drugs with fewer side effects


Adiponectin is a metabolic link between obesity and bone mineral density

November 25, 2008 - EurekAlert / Experimental Biology and Medicine

Researchers have discovered that adiponectin, a protein secreted from adipocytes, is a metabolic link that can explain, in part, the known positive relationship between obesity and both bone mineral density and reduced susceptibility to fractures.


UT Southwestern researchers find clue to safer obesity drugs

November 25, 2008 - UT Southwestern Medical Center / Neuron

Once hailed as a miracle weight-loss drug, Fen-phen was removed from the market more than a decade ago for inducing life-threatening side effects, including heart valve lesions. Scientists are now trying to understand how Fen-phen behaves in the brain in order to develop safer anti-obesity drugs with fewer side effects.


Why women should eat less, move more and consider wearing transdermal HRT patches during menopause

November 24, 2008 - EurekAlert / Obesity Reviews

Weight and appetite experts from around the world met at a conference in Bangkok earlier this year to discuss sex differences in obesity. One line of discussion looked at factors leading to women's weight gain during menopause, and how it might be avoided


Sealing off portion of intestinal lining treats obesity, resolves diabetes in animal model

November 24, 2008 - EurekAlert / Obesity

Lining the upper portion of the small intestine with an impermeable sleeve led to both weight loss and restoration of normal glucose metabolism in an animal model of obesity-induced diabetes. Investigators report that the procedure reproducing several aspects of gastric bypass surgery led to a significant reduction in the animals' food intake and a resolution of diabetes symptoms


Exercise helps overweight children reduce anger expression

November 24, 2008 - Medical College of Georgia / Pediatric Exercise Science

Regular exercise seems to reduce anger expression in overweight but otherwise healthy children. Aerobic exercise may be an effective strategy to help overweight kids reduce anger expression and aggressive behavior


Telephone counseling may be as effective as face-to-face counseling in weight loss maintenance

November 24, 2008 - EurekAlert / Archives of Internal Medicine

Face-to-face and telephone follow-up sessions appear to be more effective in the maintenance of weight loss for women from rural communities compared with weight loss education alone. In addition, telephone counseling appears to be just as effective as face-to-to face counseling for weight loss management


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